Palabras clave
rs2241766
frecuencia alélica
obesidad
alteraciones metabólicas
Cómo citar
Resumen
La adiponectina es secretada por células adiposas y parece ejercer efectos metabólicos favorables. Polimorfismos en el gen ADIPOQ podrían estar asociados con la obesidad y riesgo cardiometabólico. El objetivo de este estudio fue evaluar la posible asociación del polimorfismo rs2241766 (ADIPOQ45 T/G) con el fenotipo obeso en una población del municipio Maracaibo, estado Zulia. El polimorfismo fue investigado en grupos de individuos obesos (OB) y no obesos (No OB) por PCR-RFLP. La frecuencia genotípica del polimorfismo rs2241766 en la población fue de 80% para la variante homocigota ADIPOQ45 T/T y 20% para la variante heterocigota ADIPOQ45 T/G. El genotipo homocigoto ADIPOQ45 G/G no fue detectado en este estudio. Las frecuencias alélicas del polimorfismo ADIPOQ45 T y G fueron de 90% y 10%, respectivamente. La frecuencia del alelo ADIPOQ 45G fue superior en los OB, pero la distribución genotípica y alélica homogénea encontrada entre ambos grupos apoya la ausencia de asociación de algún alelo particular con obesidad. Los portadores del genotipo ADIPOQ 45 T/G exhibieron valores superiores en indicadores antropométricos de obesidad, niveles de lípidos séricos, glicemia basal, presión arterial y bajos niveles séricos de HDL-colesterol, revelando un perfil metabólico desfavorable comparado con individuos con genotipo ADIPOQ45 T/T, pero no hubo diferencias significativas entre los genotipos. Este estudio permitió establecer que la población evaluada exhibe una frecuencia alélica de ADIPOQ45 T/G, similar a la reportada en poblaciones europeas. Los resultados obtenidos coinciden con investigaciones que reportan efectos modestos del genotipo heterocigoto ADIPOQ45 T/G con obesidad y otras alteraciones metabólicas.
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Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.
Derechos de autor 2022 María Patricia Sanchez, Nailet Arráiz, Karen Cubillan, Vanessa Matheus, Deirymar Montero